C

Chris Neville

VP at Evidently

Contributor since November 2025

Specialty:
Anesthesiology
AI Tool:
Evidently
Specialty:
Anesthesiology
AI Tool:
Evidently
Systematically review the patient's chart for any data—historical, clinical, or laboratory—that may indicate an active or occult infection, especially given the blunted immune response typical of immunosuppressed patients. Include in search: Organ(s) Transplanted, surgical complications, nosocomial/hospital-acquired infections (SSI, UTI, HAP, C. diff), and donor-derived infections, opportunistic infections (CMV, PCP, Aspergillus, Nocardia, EBV, Toxoplasmosis, Cryptococcus), Community-acquired infections, but also possible late opportunistic infections (CMV, BK virus, Herpes Zoster) and malignancy (PTLD), Immunosuppression Regimen/Changes, Any recent escalations/increases in dose, any recent dose hold or reduction due to toxicity, prophylaxis status: Is the patient currently receiving or has recently completed prophylaxis for CMV (Valganciclovir), PCP (Bactrim), or Fungi (Fluconazole, Rejection History: Any episodes of allograft rejection (acute or chronic) Date and treatment given (especially T-cell depleting agents like ATG). Fever: Highest documented temperature, Vitals: New or worsening tachycardia, tachypnea, or hypotension (qSOFA criteria), Fatigue/Malaise: New, unexplained, or progressive weakness/lethargy, Allograft Dysfunction (Organ-Specific): Look for functional decline, which can be the only sign of infection. Kidney: Decreased urine output, rising creatinine/BUN. Liver: Rising LFTs (AST, ALT, Bilirubin), worsening synthetic function. Lung: New or increased O2 requirement, progressive cough, dyspnea. Heart: Signs of heart failure, new dysrhythmias. Identify the primary site of infection and review the chart for these specific findings: Review most recent Chest X-ray or CT for infiltrates, nodules, or ground-glass opacities (classic for PJP/Viral). Labs: Respiratory viral PCR panel (Flu, RSV, COVID), CMV/EBV PCR. Stool Studies: C. diff toxin PCR, CMV PCR in blood/tissue (if endoscopy performed). Labs: Liver enzymes (if hepatic involvement). Imaging: Review recent MRI/CT Head. Labs: Documented CSF analysis (if LP performed), Cryptococcal Antigen, Toxoplasmosis serology, EBV PCR (for PTLD). Urine: Urinalysis (UA) for pyuria/leukocytes (often subtle). Cultures: Status of Urine Culture & Sensitivity. Labs: BK Virus PCR/Viral Load (Kidney OTR). Cultures: Wound/Drainage Culture & Sensitivity. Labs: Status of Blood Cultures. Imaging: Ultrasound/CT for deep fluid collections (abscess/lymphocele). Leukopenia/Neutropenia: Low white blood cell or neutrophil count (increases susceptibility to bacteria/fungi). Lymphopenia: Low lymphocyte count (<1000/mm³) (indicates T-cell suppression and high risk for viral/opportunistic infections). Infection Surveillance Labs: CMV PCR/Viral Load: Is the patient viremic? What is the trend? (Most common viral opportunistic infection). EBV PCR/Viral Load: Elevated load is a risk factor for PTLD (which presents like an infection). Galactomannan or Beta-D-Glucan: Elevated fungal markers. Immunosuppressant Levels: Trough Levels: Document recent Calcineurin Inhibitor (Tacrolimus/Cyclosporine) trough levels. High levels correlate with higher infection risk. Cultures/Swabs: Status of all pending or recent cultures (Blood, Urine, Sputum, Wound). Any positive results, including the last sensitivity report.
Specialty:
Infectious Disease
AI Tool:
Evidently
Specialty:
Emergency Medicine
AI Tool:
Evidently
Systematically search the patient's electronic medical record (EMR), including all past visit notes, growth charts, injury documentation, and social service history, for documented physical, behavioral, and caregiver red flags that may indicate potential child abuse or neglect. Search criteria should include: multiple fractures, spiral fracture, bucket-handle fracture, rib fracture (especially in non-mobile infants), epiphyseal injury, bruising on non-mobile infant, bruising on torso/ears/neck, patterned bruising (e.g., belt, hand print), discrepancy in dating of bruises, glove-and-stocking burn pattern, immersion burn, circular burns, splash/spill injury, subdural hematoma, retinal hemorrhage, Shaken Baby Syndrome, inconsistent history of fall, failure to thrive, severe malnutrition, untreated illness, missed immunizations/appointments, poor hygiene, extreme aggressiveness, passivity, hyper-vigilance, flat affect, fear of going home, inappropriate sexual knowledge/behavior, child fears physical exam, avoids caregiver eye contact, child flinches at sudden movements or touch, alcohol intoxication, illicit drug exposure, history provided by caregiver is inconsistent, injury mechanism does not match severity, caregiver delays seeking care, caregiver indifferent to child's pain, overly demanding/critical of child, caregiver reluctant to leave child alone, CPS involvement, protective services, child removed from home, documented family violence, domestic violence, few social contacts, family moves frequently, no available babysitters/support system
Specialty:
Emergency Medicine
AI Tool:
Evidently